Chromosomal fragility and human genetic disorders
نویسندگان
چکیده
منابع مشابه
Chromosomal and Multifactorial Genetic Disorders with Oral Manifestations
The chromosomal disorders are individually rare, but collectively they are common whereas the multifactorial disorders are the most common form of genetic disorders. The chromosomal anomalies typically arise from alterations in the DNA containing chromosomal regions and can be reliably detected by karyotype analysis, whereas the multifactorial disorders demonstrate multi-gene as well as environ...
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Yeast has been a very helpful organism for centuries, especially with respect to fermentation of sugars and production of bread. However, for an even longer time, yeast has been a distant relative of humans having diverged from a common ancestor, about one billion years ago. More than one third of the yeast genes have human counterparts, despite this evolutionary distance. Yeast and human ortho...
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Infertility in humans is surprisingly common occurring in approximately 15% of the population wishing to start a family. Despite this, the molecular and genetic factors underlying the cause of infertility remain largely undiscovered. Nevertheless, more and more genetic factors associated with infertility are being identified. This review will focus on our current understanding of the chromosoma...
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Chromosomal aberrations, and their associated syndromes of dysmorphism and malformations of multiple organ systems, have been long recognized as significant causes of severe mental impairment. With a few major exceptions, these clinical syndromes have only recently been catalogued as systematically ( 1, 2) as have been single-gene disorders. The neuropathologic features of many of these syndrom...
متن کاملHuman chromosome fragility.
Fragile sites are heritable specific chromosome loci that exhibit an increased frequency of gaps, poor staining, constrictions or breaks when chromosomes are exposed to partial DNA replication inhibition. They constitute areas of chromatin that fail to compact during mitosis. They are classified as rare or common depending on their frequency within the population and are further subdivided on t...
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ژورنال
عنوان ژورنال: Indian Journal of Clinical Biochemistry
سال: 2000
ISSN: 0970-1915,0974-0422
DOI: 10.1007/bf02867554